Police, ambulance and fire crews attended the scene in New South Promenade at 9.15pm, close to the Burlington Road West tram stop.
Pictures show a car on top of another, with extensive damage to both and further damage to a third car.
Debris from the crash can be seen scattered across the road, which was closed for around two hours while emergency services responded.
Fire crews helped release two people from one of the wrecked cars and the pair were treated at the scene by paramedics.
Details on their injuries and any other casualties have not been made available at this stage. North West Ambulance Service were approached for comment.
Tram services between Starr Gate and Little Bispham were canceled until after 11pm to allow the emergency services to use the tram tracks to reach the scene.
Calls to reduce traffic speeds on busy Blackpool road near Prom